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Cardiomyocytes, heart cells, iPSC

Beating Cardiomyocytes (heart cells) made from Induced Pluripotent Stem Cells (iPSC) which were derived from adult human cells that have been reprogrammed back into an embryonic-like pluripotent state.

Codding, S.J. and Trudeau, M.C. (2019) The hERG potassium channel intrinsic ligand regulates N- and C-terminal interaction and channel closure. J. Gen. Physiol. 151(4)478-488.  PMCID: PMC6445578

Jones, D.K., Johnson, A., Roti Roti, E.C., Liu, F., Uelmen, R., Ayers, R.A., Baczko, I., Tester, D.J., Ackerman, M.J., Trudeau, M.C., Robertson, G.A.  (2018)  Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG/KCNH2 proteins in the heart.  J Cell Sci.  Mar 22;131(6).  PMCID: PMC5897710

McNally, B.A., Pendon, Z., Trudeau, M.C. (2017) hERG1a and hERG1b potassium channel subunits directly interact and preferentially form heteromeric channelsJ Biol Chem. Dec 29;292(52):21548-21557. PMCID: PMC5766944

Liu, Q-N and Trudeau M.C. (2015)  Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived CardiomyocytesPLoS ONE10 (4) e0123951. PMCID: PMC4414485.

Jones, D.K., Liu, F., Vaidyanathan, Eckhardt, L.L., Trudeau, M.C. and Robertson, G.A. (2014) hERG 1b is Critical for Human Cardiac Repolarization. Proceedings of the National Academy of Science, USA. 111(50) 18073-18077. PMCID: PMC4273358.

Gustina, A.S. and Trudeau, M.C. (2013) The eag domain regulates hERG channel inactivation via a direct interaction. The Journal of General Physiology, 141(2), 229-241. PMCID: PMC3557309.

Brelidze, T.I., Gianulis, E.G., DiMaio, F., Trudeau, M.C. and Zagotta, W.N. (2013) Structure of the C-terminal region of an ERG channel and functional implications. Proceedings of the National Academy of Sciences, USA. 110(28), 11648-11653. PMCID: PMC3710865

Gianulis E.C., Liu Q., Trudeau M.C. (2013) Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channelsJ Gen Physiol. 2013 Oct;142(4):351-366.PMCID: PMC3787778

Gustina, A.S. and Trudeau, M.C. (2013) The eag domain regulates hERG channel inactivation via a direct interaction.The Journal of General Physiology, 141(2), 229-241. PMCID: PMC3557309.

Brelidze, T.I., Gianulis, E.G., DiMaio, F., Trudeau, M.C. and Zagotta, W.N. (2013) Structure of the C-terminal region of an ERG channel and functional implicationsProceedings of the National Academy of Sciences, USA. 110(28), 11648-11653. PMCID: PMC3710865

Gustina, A.S. and Trudeau, M.C. (2012) hERG Potassium Channel Regulation by the N-terminal eag domainCellular Signalling.

Trudeau, M.C. (2012) Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels.The Journal of General Physiology, 140(5), 457-461. PMCID: PMC3483117.

Gustina, A.S. and Trudeau, M.C. (2011) hERG potassium channel gating is mediated by N- and C-terminal region interactionsJournal of General Physiology, 137, 315-325. PMCID: PMC3047612

Gianulis, E.C. and Trudeau, M.C. (2011) Rescue of aberrant gating by a genetically-encoded PAS domain in several long QT syndrome mutant human ether á go-go related gene potassium channelsJournal of Biological Chemistry, 286, 22160-22169. PMCID: PMC3121360

Trudeau, M.C., Leung, L.M., Roti Roti, E., and Robertson, G.A. (2011) hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: A possible mechanism for Long QT syndromeJournal of General Physiology, 138(6), 581-592. PMCID: PMC3226966

Gustina, A.S. and Trudeau, M.C. (2009)  A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsProceedings of the National Academy of Sciences. 106:13082-13087. PMCID: PMC2722319

Shepard P.D. and Trudeau, M.C.  (2008) Emerging roles for ether á go-go related gene potassium channels in the brain. Journal of Physiology, Oct 15;586 (Pt 20):4785-6. PMCID: PMC2614064

Trudeau, M.C. and Zagotta, W.N. (2004) Dynamics of Ca2+-calmodulin dependent inhibition of rod cyclic nucleotide-gated channels measured by patch-clamp fluorometryJournal of General Physiology.  124(3), 211-223.  PMCID: PMC2233886

Trudeau, M.C. and Zagotta, W.N. (2003) Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channelsJournal of Biological Chemistry. 278, 18705-18708.

Trudeau, M.C. and Zagotta, W.N. (2002) An intersubunit interaction regulates trafficking of rod cyclic nucleotide-gated channels and is disrupted in an inherited form of blindnessNeuron. 34, 197-207.

Trudeau, M.C. and Zagotta, W.N. (2002) Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channelsProc. Natl. Acad. Sci. USA, 99(12), 8424-8429.

Trudeau, M.C., Titus, S.A., Branchaw, J.L., Ganetzky, B. and Robertson, G.A. (1999) Functional analysis of a mouse brain Elk-type K+ channelJournal of Neuroscience. 19, 2906-2918.

Trudeau, M.C., Warmke, J.W., Ganetzky, B. and Robertson, G.A. (1995) HERG, a human inward rectifier in the voltage-gated potassium channel familyScience. 269, 92-95.